Protein Details: β4 (Calcium-activated potassium channel subunit beta-4)

Protein ID

ICDB_Pro_1524

Protein Name

β4 (Calcium-activated potassium channel subunit beta-4)

Gene Name

Kcnmb4

Organism

Mus musculus (Mouse)

Length

210 amino acids

AlphaFoldDB

AF-Q9JIN6-F1-model_v4.pdb

Function

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1; thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel; but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations (By similarity)

Sequence

MAKLRVSYEYTEAEDKSIRLGLFLIVSGILSLFIFGFCWLSPALQDLQATAANCTVLSVQQIGEVFECTFTCGTDCRGTSQYPCVQVYVNNSESNSRALLHSDQHQLLTNPKCSYIPPCKRENQKNSESVMNWQQYWKDEIGSQPFTCYFNQHQRPEDVLLQRTHDEIALLHCFLWPVVAFVVGVLIVVLTICAKSLAVKAEAMKKRKFS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1523/jneurosci.20-10-03563.2000; 10.1101/gr.2596504; 10.1073/pnas.1423094112

RefSeq

NP_067427.1